Chromophobe Renal Cell Carcinoma (ChRCC) with Osteosarcomatous Differentiation and Osseous Pulmonary Metastasis- A Case Report
Published: 2023-09-16
Page: 108-112
Issue: 2023 - Volume 6 [Issue 1]
Philip Tojo Kalloopparamban *
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Balagopal Nair T.
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Tharun B. K.
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Sandeep R. Nath
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Shwetana Palavalasa
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Prakhar Saxena
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
*Author to whom correspondence should be addressed.
Abstract
Chromophobe renal cell carcinoma, a subtype of Renal Cell Carcinoma (RCC) is associated with a better prognosis than clear cell RCC and comprises about 3-5 % of all RCCs. It is believed to originate from the intercalated cells of the distal nephron (Steven C. Campbell MD, 2016). Sarcomatoid differentiation can occur with any RCC, in which high-grade spindle cells co-exist with epithelial areas of the tumor. It suggests transformation to higher grade malignancy and an ominous outcome. The sarcomatoid component is homologous (Akin to parent RCC cells) in the majority of cases. We herein report a case of ChRCC with osteosarcomatous (heterologous) differentiation in an elderly gentleman, who developed pulmonary metastasis with an osseous component. Although metastasis is very rare in Chromophobe RCC, Sarcomatoid differentiation.
Keywords: Chromophobe renal cell carcinoma, sarcomatoid differentiation, osteosarcomatous (heterologous) differentiation, pulmonary metastasis
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References
Thoenes WSS. Human chromophobe cell renal carcinoma. Virchows Arch. 1985;48: 207-217.
Volpe A. Chromophobe renal cell carcinoma (RCC): Oncological outcomes and prognostic factors in a large multicentre series. BJU International. 2012;110(1):76-83.
DOI:10.1111/j.1464-410X.2011.10690.x
Amin MB, Paner GP, Alvarado-Cabrero I, Young AN, Stricker HJ, Lyles RH, Moch H. Chromophobe renal cell carcinoma: Histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases Am. J. Surg. Pathol. 2008;32:1822-1834.
DOI:10.1097/PAS.0b013e3181831e68
Shuch BBG. Sarcomatoid renal cell carcinoma: A comprehensive review of the biology and current treatment strategies. Oncologist. 2012;46-54.
Tanaka YKT. Chromophobe renal cell carcinoma with concomitant sarcomatoid transformation and osseous metaplasia: A case report;. BMC Urol, 2013;72.
Akhtar MTA. Sarcomatoid renal cell carcinoma: The chromophobe connection. Am J Surg Pathol. 1997;21(10): 1188-95.
Brunelli M, SRG. Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma. Mod Pathol. 2007;303-309.
Gabriela Quiroga-Garza HK. Sarcomatoid chromophobe renal cell carcinoma with heterologous sarcomatoid elements. Archives of Pathology & Laboratory Medicine. 2009;1857-1860.
Ged Ye. Metastatic chromophobe renal cell carcinoma: Presence or absence of sarcomatoid differentiation determines clinical course and treatment outcomes. Clinical Genitourinary Cancer; 2019.
Amin MB, MP A. Prognostic impact of histological subtyping of adult renal epithelial neoplasms. Am J Surg Pathol. 2002;26(3):281–291.
Colomba Emeline ea. Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A renal cross channel group study. European Journal of Cancer. 2017;80:55-62.
William W, Daniel JG. Calcified renal masses. Radiology. 1972;103(3):503-508
Hötker AM, Karlo CA, Di Paolo PL, Zheng J, Moskowitz CS, Russo P, Hricak H, Akin O. Renal cell carcinoma: Associations between tumor imaging features and epidemiological risk factors Eur. J. Radiol. 2020;129. Article 109096.
DOI:10.1016/j.ejrad.2020.109096
Jikuya R, Johnson TA, Maejima K, An J, Ju YS, Lee H, Ha K, Song W, Kim Y, Okawa Y, Sasagawa S. Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma. Ebiomedicine. 2023;92.
Msaouel P, Genovese G, Tannir NM. Renal cell carcinoma of variant histology: Biology and therapies. Hematology/Oncology Clinics; 2023.
Whaley RD, et al. Clinicopathologic and immunohistochemical characterization of sarcomatoid chromophobe renal cell carcinoma: An analysis of 22 cases. Am. J. Surg. Pathol; 2022.
Daugherty M, Blakely S, Shapiro O, Vourganti S, Mollapour M, Bratslavsky G. Chromophobe renal cell carcinoma is the most common nonclear renal cell carcinoma in young women: Results from the SEER database. The Journal of urology. 2016;195(4 Part 1): 847-51.
Casuscelli J, Becerra MF, Seier K, Manley BJ, Benfante N, Redzematovic A, Stief CG, Hsieh JJ, Tickoo SK, Reuter VE, Coleman JA. Chromophobe renal cell carcinoma: Results from a large single-institution series. Clinical Genitourinary Cancer. 2019;17(5):373-9.
Steven C, Campbell Pa. Campbell-Walsh Urology (11 ed.); 2016.