Chromophobe Renal Cell Carcinoma (ChRCC) with Osteosarcomatous Differentiation and Osseous Pulmonary Metastasis- A Case Report
Published: 2023-09-16
Page: 108-112
Issue: 2023 - Volume 6 [Issue 1]
Philip Tojo Kalloopparamban *
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Balagopal Nair T.
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Tharun B. K.
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Sandeep R. Nath
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Shwetana Palavalasa
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
Prakhar Saxena
Department of Urology, Rajagiri Hospital, Aluva, Kochi, India.
*Author to whom correspondence should be addressed.
Abstract
Chromophobe renal cell carcinoma, a subtype of Renal Cell Carcinoma (RCC) is associated with a better prognosis than clear cell RCC and comprises about 3-5 % of all RCCs. It is believed to originate from the intercalated cells of the distal nephron (Steven C. Campbell MD, 2016). Sarcomatoid differentiation can occur with any RCC, in which high-grade spindle cells co-exist with epithelial areas of the tumor. It suggests transformation to higher grade malignancy and an ominous outcome. The sarcomatoid component is homologous (Akin to parent RCC cells) in the majority of cases. We herein report a case of ChRCC with osteosarcomatous (heterologous) differentiation in an elderly gentleman, who developed pulmonary metastasis with an osseous component. Although metastasis is very rare in Chromophobe RCC, Sarcomatoid differentiation.
Keywords: Chromophobe renal cell carcinoma, sarcomatoid differentiation, osteosarcomatous (heterologous) differentiation, pulmonary metastasis