Efficacy and Reliability of Matrix PRP in Erectile Dysfunction Therapy: Experience of the Regenerative Medicine Center at CHEIKH KHALIFA University Hospital, Morocco
Published: 2024-10-30
Page: 81-87
Issue: 2024 - Volume 7 [Issue 1]
Moussaab Rachid *
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Ghassane EL OMRI
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Hamza Rais
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Taghouane Anas
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Sabour Mahmoud
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Boularbah Karim
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Younes Houry
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Abdeljalil Heddat
Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Platelet-rich plasma is defined as a plasma fraction derived from autologous blood with a platelet concentration above the normal range. It constitutes a reservoir of bioactive proteins, mainly growth factors, which are essential for initiating and accelerating tissue repair and regeneration. Biological stimulation of damaged tissue with platelet concentrates (PRP) involves harnessing the tissue's regenerative potential by recruiting local stem cells.
Methods: This is a retrospective study spread over 12 months (March 2021 to March 2022) involving a sample of 40 patients with erectile dysfunction with an age ranging from 34 to 71 years and an average of 52.5 years. Initial assessment and follow-up of patients was based on the International Index of Erectile Function (IIEF5) with a score of (5-10) indicating severe erectile dysfunction, (11-15) moderate, (16-20) mild, (21-25) no erectile dysfunction.
Results: All in all, a significant improvement in IEF5 was demonstrated in all patients, with the mean IEF5 of all patients rising uniformly after each dose, plateauing at months 3 and 6.
Conclusion: The IEF5 of 55% of patients improved after the 1st dose, with 70% of patients showing improvement after the 2nd dose, then stagnating at 80% after the3rd dose.
Keywords: Platelet-rich plasma, autologous blood, growth factors, regeneration, erectile dysfunction