Study on Semen Quality among Men Seeking Infertility Treatment in Tamale, Ghana

Simon Bannison Bani *

Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Raymond Anachem

Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana and Chemical Pathology Unit, Tamale Teaching Hospital, Ghana.

Moses Banyeh

Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Peter Paul M. Dapare

Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Yussif Adams

Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Charles Nkansah

Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Kofi Mensah

Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Samuel Kwasi Appiah

Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Fathea Bani

School of Medicine and Health Sciences, University for Development Studies, Tamale Ghana.

Hisham Osumanu

Department of Infectious Diseases, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Gabriel Abbam

Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

Samira Daud

Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.

*Author to whom correspondence should be addressed.


Abstract

Background: Standard semen analysis is the surrogate measure of male fertility in clinical practice. According to recent studies, there is a slight increase in percentage of couples who are facing infertility problems globally. This study determined the semen quality trends of men seeking infertility treatment in the Tamale Metropolis, Ghana.

Methods: This is a retrospective cross-sectional study with data from archival records over a period of six years; from January 2015 to December 2020.

Results: A total of 785 semen analysis reports of men seeking infertility treatment over a period of 6 years were considered. In all, 187 (23.82%) had normozoospermia, 347 (44.20%) had oligozoospermia, and 251 (31.97%) had azoospermia. Out of the 785 subjects, 344 (57.91%) had abnormal semen parameters even though their semen volume was normal. Percentage abnormal motility, morphology and viability rose sturdily from 5.74%, 8.14%, and 12.59 in 2015 through 20.87%, 18.77%, 19.85% in 2017 to 26.85%, 27.95 and 21.55 respectively in 2020. Abnormal pH and volume also rose from 8% and 8.59 in 2015 to 23.69 and 24.91 respectively in 2020.

The highest variances were seen in the age group 31-40 years (p<0.0001). Males with hypospermia were 56% less likely to have abnormal sperm concentration than those with hyperspermia (OR=0.44; 95% CI=0.23–0.83; p=0.012).

Conclusion: This study shows a high rate of abnormal semen quality of male partners of infertile couples. The trend of oligozoospermia increased during the past six years while the trend of normozoospermia remain fairly constant. Oligoasthenoteratozoospermia has increased consistently from 2015 to 2020, buttressing the fact that, male infertility is on the ascendancy.

Keywords: Infertility, semen quality, oligozoospermia, azoospermia, morphology, motility, sperm count


How to Cite

Bani, S. B., Anachem, R., Banyeh, M., Dapare, P. P. M., Adams, Y., Nkansah, C., Mensah, K., Appiah, S. K., Bani , F., Osumanu , H., Abbam, G., & Daud, S. (2023). Study on Semen Quality among Men Seeking Infertility Treatment in Tamale, Ghana. Asian Journal of Research and Reports in Urology, 6(1), 27–36. Retrieved from https://journalajrru.com/index.php/AJRRU/article/view/88

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References

Jensen TK, et al. Poor semen quality may contribute to recent decline in fertility rates. Hum Reprod. 2002;17(6):1437-40.

Sengupta P, Nwagha U, Dutta S, Krajewska-Kulak E, Izuka E. Evidence for decreasing sperm count in African population from 1965 to 2015. Afr Health Sci. 2017;17(2):418-27. DOI: 10.4314/ahs.v17i2.16, PMID 29062337.

Blay RM, Pinamang AD, Sagoe AE, Owusu EDA, Koney NK, Arko-Boham B. Influence of lifestyle and environmental factors on semen quality in Ghanaian men. Int J Reprod Med. 2020;2020:6908458.

DOI: 10.1155/2020/6908458, PMID 33150165.

Dain L, Auslander R, Dirnfeld M. The effect of paternal age on assisted reproduction outcome. Fertil Steril. 2011;95(1):1-8. DOI: 10.1016/j.fertnstert.2010.08.029, PMID 20932518.

GSS, demographic and health survey report; 2007.

Milardi D, Grande G, Sacchini D, Astorri AL, Pompa G, Giampietro A, et al. Male fertility and reduction in semen parameters: A single tertiary-care center experience. Int J Endocrinol. 2012;2012:649149. DOI: 10.1155/2012/649149, PMID 22319527.

Li WN, Jia MM, Peng YQ, Ding R, Fan LQ, Liu G. Semen quality pattern and age threshold: A retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017. Reprod Biol Endocrinol. 2019;17(1):107.

DOI: 10.1186/s12958-019-0551-2, PMID 31815629.

Butt F, Akram N. Semen analysis parameters: Experiences and insight into male infertility at a tertiary care hospital in Punjab. J Pak Med Assoc. 2013;63(5):558-62. PMID 23757979.

Rikhasor RM, et al. Semen analysis of infertile men and plasma levels of LH, FSH, and testosterone in oligospermia. Med Channel. 2001;7(2):30-2.

Samal S, et al. Epidemiological study of male infertility. Indian Med Gaz. 2012;5: 174-80.

Ugwuja EI, Ugwu NC, Ejikeme BN. Prevalence of low sperm count and abnormal semen parameters in male partners of women consulting at infertility clinic in Abakaliki, Nigeria. Afr J Reprod Health. 2008;12(1):67-73.

PMID 20695157.

Corona G, Jannini EA, Vignozzi L, Rastrelli G, Maggi M. The hormonal control of ejaculation. Nat Rev Urol. 2012;9(9): 508-19. DOI: 10.1038/nrurol.2012.147, PMID 22869001.

Ahmed M, et al. Semen analysis of infertile Sudanese males in Gezira state central Sudan. Sudanese J Public Health. 2009;4(3):340-4.

Nwafia WC, Igweh JC, Udebuani IN. Semen analysis of infertile Igbo males in Enugu, Eastern Nigeria. Niger J Physiol Sci. 2006;21(1-2):(67-70). DOI: 10.4314/njps.v21i1-2.54254, PMID 17242721.

Frydman R, Grynberg M. Introduction: male fertility preservation: innovations and questions. Fertil Steril. 2016;105(2): 247-8. DOI: 10.1016/j.fertnstert.2015.12.012, PMID 26746134.

Chinyere Nsonwu-Anyanwu AC, Raymond Ekong E, Jeremiah Offor S, Francis Awusha O, Chukwuma Orji O, Idiongo Umoh E, et al. Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study. Int J Reprod Biomed. 2019;17(3):163-74.DOI: 10.18502/ijrm.v17i3.4515, PMID 31435598.

Bhardwaj A, Verma A, Majumdar S, Khanduja KL. Status of vitamin E and reduced glutathione in semen of oligozoospermic and azoospermic patients. Asian J Androl. 2000;2(3):225-8. PMID 11225982.

Gyasi-Sarpong CK, Maison POM, Koranteng AK. The pattern of male infertility in Kumasi, Ghana. Afr J Infertil Assist Conception. 2017;2(1):3.

Ikechebelu JI, Adinma JI, Orie EF, Ikegwuonu SO. High prevalence of male infertility in southeastern Nigeria. J Obstet Gynaecol. 2003;23(6):657-9. DOI: 10.1080/01443610310001604475, PMID 14617473.

Kumar N, Choudhari AR, Singh AK. Prevalence of male factor infertility in last ten years at a rural tertiary care centre of central India: A retrospective analysis. Indian Journal of Obstetrics and Gynaecology Research. 2015;2(3):132-6.

Jequier AM. Semen analysis: A new manual and its application to the understanding of semen and its pathology. Asian J Androl. 2010;12(1):11-3. DOI: 10.1038/aja.2009.12, PMID 20111075.

Das M, Al-Hathal N, San-Gabriel M, Phillips S, Kadoch IJ, Bissonnette F, et al. High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age. J Assist Reprod Genet. 2013;30(6):843-8.

DOI: 10.1007/s10815-013-0015-0, PMID 23722935.

Urhoj SK, Jespersen LN, Nissen M, Mortensen LH, Nybo Andersen AM. Advanced paternal age and mortality of offspring under 5 years of age: A register-based cohort study. Hum Reprod. 2014;29(2):343-50.

DOI: 10.1093/humrep/det399, PMID 24316515.

Oliveira JBA, Petersen CG, Mauri AL, Vagnini LD, Baruffi RLR, Franco JG. The effects of age on sperm quality: an evaluation of 1,500 semen samples. JBRA Assist Reprod. 2014;18(2):34-41. DOI: 10.5935/1518-0557.20140002, PMID 35761724.

Owolabi AT, Fasubaa OB, Ogunniyi SO. Semen quality of male partners of infertile couples in Ile-Ife, Nigeria. Niger J Clin Pract. 2013;16(1):37-40. DOI: 10.4103/1119-3077.106729, PMID 23377467.

Crosnoe LE, Kim ED. Impact of age on male fertility. Curr Opin Obstet Gynecol. 2013;25(3):181-5. DOI: 10.1097/GCO.0b013e32836024cb, PMID 23493186.

Lirdi LC, Stumpp T, Sasso-Cerri E, Miraglia SM. Amifostine protective effect on cisplatin‐treated rat testis. The anatomical record. Anat Rec (Hoboken). 2008;291(7):797-808. DOI: 10.1002/ar.20693, PMID 18543292.

Park HJ, Kim JS, Lee R, Song H. Cisplatin induces apoptosis in mouse neonatal testes organ culture. Int J Mol Sci. 2022;23(21):13360. DOI: 10.3390/ijms232113360, PMID 36362147.

Stanworth RD, Jones TH. Testosterone for the aging male; current evidence and recommended practice. Clin Interv Aging. 2008;3(1):25-44. DOI: 10.2147/cia.s190, PMID 18488876.

Harris ID, Fronczak C, Roth L, Meacham RB. Fertility and the aging male. Rev Urol. 2011;13(4):e184-90. PMID 22232567.

Leisegang K, Henkel R, Agarwal A. Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system. Am J Reprod Immunol. 2019;82(5):e13178. DOI: 10.1111/aji.13178, PMID 31373727.

WHO. WHO laboratory manual for the examination of human semen and sperm–cervical mucus interactions. 1992;1-107.

Elzanaty S. Association between age and epididymal and accessory sex gland function and their relation to sperm motility. Arch Androl. 2007;53(3):149-56. DOI: 10.1080/01485010701225667, PMID 17612873.

Henkel R, Maass G, Schuppe HC, Jung A, Schubert J, Schill WB. Molecular aspects of declining sperm motility in older men. Fertil Steril. 2005;84(5):1430-7. DOI: 10.1016/j.fertnstert.2005.05.020, PMID 16275240.